Mental health
Depression: symptoms, causes, treatment and how long it lasts
Depression is more than feeling unhappy or fed up for a few days. The NHS describes it as a real illness in which you feel persistently sad for weeks or months, often with loss of interest, tiredness and poor sleep. See a GP if you have symptoms most of the day, every day, for more than 2 weeks. Most people can make a full recovery with the right treatment.
Last checked: 2026-10-11
Key facts
At a glance.
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What it is
The NHS says depression is a real illness with real symptoms, not a sign of weakness or something you can "snap out of". You feel persistently sad for weeks or months, rather than just a few days.
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Main symptoms
Continuous low mood or sadness, feeling hopeless, no motivation or interest in things, tearfulness, feeling guilty or irritable, poor sleep, tiredness, changes in appetite and unexplained aches and pains.
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When to see a GP
The NHS says to see a GP if you have symptoms of depression for most of the day, every day, for more than 2 weeks, or if you have thoughts of suicide or self-harm.
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Causes
There is no single cause. The NHS lists stressful life events, family history, personality, pregnancy and giving birth, menopause, loneliness, alcohol and drugs, and illness. Causes often combine.
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Diagnosis
The NHS says there are no physical tests for depression. A GP asks about how you are feeling and how it affects your daily life, and may use a questionnaire and some blood or urine tests to rule out other conditions.
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Treatment
Self-help, talking therapies and antidepressant medicines, depending on severity. You can refer yourself to an NHS talking therapies service without seeing a GP.
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Recovery
The NHS says that with the right treatment and support, most people with depression can make a full recovery.
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Urgent help
Call 999 or go to A&E if someone's life is at risk or you do not feel you can keep yourself or someone else safe. For urgent help with your mental health, use 111 online or call 111 and select the mental health option.
What are the symptoms of depression?
The NHS says the symptoms of depression can be complex and vary widely between people, and that you are unlikely to have all of the symptoms listed. They persist for weeks or months and are bad enough to interfere with your work, social life and family life. Depression can come on gradually, so it can be hard to notice that something is wrong, and it can sometimes take a friend or family member to suggest it.
| Type | Examples |
|---|---|
| Psychological | Continuous low mood or sadness; feeling hopeless and helpless; low self-esteem; tearfulness; guilt; irritability and intolerance of others; no motivation or interest in things; difficulty making decisions; getting no enjoyment out of life; anxiety or worry; thoughts of suicide or self-harm. |
| Physical | Moving or speaking more slowly than usual; changes in appetite or weight; constipation; unexplained aches and pains; lack of energy; low sex drive; disturbed sleep, such as difficulty falling asleep or waking very early. |
| Social | Avoiding contact with friends and taking part in fewer social activities; neglecting hobbies and interests; difficulties at home, work or in family life. |
What is depression?
The NHS says most people go through periods of feeling down, but when you are depressed you feel persistently sad for weeks or months rather than just a few days. It describes depression as a real illness with real symptoms, and says it is not a sign of weakness or something you can get over by pulling yourself together.
Symptoms range from mild to severe. At its mildest you may simply feel persistently low in spirit, while severe depression can make you feel suicidal, or that life is no longer worth living. The NHS adds that many people with depression also have symptoms of anxiety.
Doctors describe depression in adults as either less severe (mild) or more severe (moderate or severe), based on the symptoms, how long it lasts and the impact on your daily life. A few people with severe depression may have symptoms of psychosis. You will usually be asked to answer a set of questions to help doctors judge how severe it is.
How is depression treated?
The NHS says treatment usually involves a combination of self-help, talking therapies and medicines, and that the treatment recommended is based on the type and severity of depression.
| Severity | What may be recommended |
|---|---|
| Mild | Watchful waiting, with a GP review after 2 to 4 weeks; guided self-help (usually 6 to 8 sessions with a therapist supporting you); exercise, including group exercise classes designed for depression; talking therapies such as CBT or counselling if it is not improving. |
| Moderate to severe | Antidepressants, often together with talking therapy. The NHS says a combination of an antidepressant and CBT usually works better than either alone. |
| Severe | Referral to a mental health team of psychologists, psychiatrists, specialist nurses and occupational therapists, who often provide intensive talking treatments as well as medicine. |
Talking therapies for depression
The NHS says a GP can refer you for talking therapies, or you can refer yourself directly to an NHS talking therapies service without a GP referral. Waiting times can be several weeks or months, and a GP can tell you how long you might wait and what to do if you get worse or need support in the meantime.
The NHS describes several types. Cognitive behavioural therapy (CBT) helps you understand your thoughts and behaviour and usually involves 8 to 16 sessions. Interpersonal therapy focuses on relationships and usually involves 8 to 16 sessions. Behavioural activation looks at links between activities and mood and usually involves 12 to 16 sessions. Counselling may be offered as 8 to 16 sessions. Individual problem-solving (6 to 12 sessions) is only recommended for more severe depression, and behavioural couples therapy (15 to 20 sessions over 5 to 6 months) may be offered if relationship problems could be contributing.
Antidepressants: what to expect
The NHS says most people with moderate or severe depression benefit from antidepressants, but not everybody does. You may respond to one and not another, and may need to try two or more before you find one that works. The different types work about as well as each other, but side effects vary.
When you start, the NHS says you should see a GP or specialist nurse every week or 2 for at least 4 weeks to check how well they are working. Symptoms should start to improve within 4 weeks. If they are working, you will need to continue at the same dose for at least 4 to 6 months after your symptoms have eased. If you have had episodes of depression in the past you may need to continue long term, and you will be reviewed at least twice a year.
The NHS says antidepressants are not addictive, but you may get withdrawal symptoms if you stop suddenly or miss a dose, so you will be advised to reduce the dose gradually. Contact a GP straight away if feelings of hopelessness or suicidal thoughts start or get worse after starting antidepressants.
| Type | Examples named by the NHS | Points to know |
|---|---|---|
| SSRIs | Sertraline, paroxetine, fluoxetine, citalopram | Usually prescribed first. Can cause nausea, headaches, dry mouth, tiredness, sleeping problems and sexual problems, which usually improve over time. |
| Tricyclics (TCAs) | Imipramine, amitriptyline | Used for moderate to severe depression. Side effects include dry mouth, blurred vision, constipation and drowsiness. |
| SNRIs | Venlafaxine, duloxetine | Can lead to a rise in blood pressure. |
| Mirtazapine | Mirtazapine | Can make you sleepy, which can help if you have difficulty getting to sleep. |
What causes depression?
The NHS says there is no single cause of depression. It can occur for a variety of reasons and has many triggers, and different causes can combine. Examples it gives include an upsetting or stressful life event such as bereavement, divorce, illness, redundancy or money worries.
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Family history: if a parent, sister or brother has had depression you are more likely to develop it, though it does not mean you definitely will.
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Personality: traits such as low self-esteem or being overly self-critical may make you more vulnerable.
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Pregnancy and giving birth: hormonal and physical changes and added responsibility can lead to postnatal depression.
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Menopause: it can sometimes trigger depression, particularly in the first few years.
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Loneliness, and alcohol or drugs: alcohol affects the chemistry of the brain and increases the risk of depression, and cannabis may bring it on, particularly in teenagers.
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Illness: a longstanding or life-threatening illness, long-term pain, a severe head injury, or in some people an underactive thyroid.
Depression in pregnancy
The NHS says you can get depression when you are pregnant, and that it is called antenatal depression. Some mood changes, such as feeling tired or irritable, are normal in pregnancy, but if you often feel low and hopeless and no longer enjoy things you used to, it says to talk to a midwife or GP. If it is not treated, symptoms can get worse and may continue after the baby is born as postnatal depression.
Treatment can include self-help, a self-help course or NHS talking therapies, and sometimes antidepressants. The NHS says antidepressants may be recommended for moderate or severe depression if you do not want psychological therapy, it has not worked, or you prefer medicine. It advises talking to a GP or the doctor in charge of your care about antidepressants that are safer to take in pregnancy, as they will usually offer the type with the lowest risk for you and your baby.
Contact a GP immediately if you start hearing or seeing things that are not real, or develop strong beliefs not shared by others. Call 999 if you think there is a danger that you might harm yourself or others.
How is depression diagnosed?
The NHS says there are no physical tests for depression, but a GP may examine you and carry out some urine or blood tests to rule out other conditions with similar symptoms, such as an underactive thyroid. The main way a GP tells whether you have depression is by asking questions about your general health and how the way you are feeling affects your daily life.
They will also ask about your medical history, previous mental health problems, home environment and lifestyle, and any recent triggers. They will ask whether you have had thoughts of suicide or self-harm, and may use a questionnaire to assess your symptoms. The NHS says any discussion with a GP is confidential, and that this will only be broken if there is a significant risk of harm to you or others.
How long does depression last?
The NHS does not give a single length of time. It says depression can come on gradually and that symptoms persist for weeks or months, and that a low mood can improve after a short period without being depression. It also says that the sooner you see a doctor, the sooner you can be on the way to recovery.
With treatment, the NHS says antidepressant symptoms should start to improve within 4 weeks, and that you will need to continue the medicine for at least 4 to 6 months after your symptoms ease. If you have had depression before, you may need to take antidepressants long term. The NHS says that with the right treatment and support, most people can make a full recovery.
Depression in children and young people
The NHS pages on depression in adults point out that depression in children and young people is covered separately. One difference it states is about medicines: SSRIs may not be prescribed for people under 18 because research shows the risk of self-harm and suicidal behaviour may increase, and fluoxetine is the only SSRI that can be prescribed for under-18s, and only when a specialist has given the go-ahead.
If you are worried about a child or teenager, the NHS advice for adults applies as a starting point: see a GP, who can refer to the right service.
When to get urgent help
The NHS says to get advice from 111 or ask for an urgent GP appointment if you need urgent help for your mental health. You can get help from 111 online or call 111 and select the mental health option, and 111 will tell you the right place to get help.
Call 999 or go to A&E now if someone's life is at risk, for example they have seriously injured themselves or taken an overdose, or you do not feel you can keep yourself or someone else safe. The NHS says a mental health emergency should be taken as seriously as a physical one and you will not be wasting anyone's time.
The NHS also lists free listening services such as Samaritans, which offer confidential support from trained volunteers, and Childline for people under 19. Contact a GP straight away if you have feelings of hopelessness or suicidal thoughts that start or get worse after starting antidepressants.
NHS and private pathways
On the NHS, depression is usually assessed by a GP, with referral to NHS talking therapies (which you can also self-refer to), and to a community mental health team if depression is severe. Medicines are prescribed by a GP or specialist.
Private psychiatrists, psychologists and therapists also see people with depression. The assessment, the evidence-based therapies and the main antidepressant options are broadly the same; the main differences are how quickly you can be seen and who pays. It is sensible to check a therapist's professional registration and to keep your GP informed about any medicines you are prescribed.
Frequently asked
Questions people ask.
Quick, plain-English answers to the questions we hear most.
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What are the symptoms of depression?
The NHS lists continuous low mood or sadness, feeling hopeless, low self-esteem, tearfulness, guilt, irritability, no motivation or interest, tiredness, disturbed sleep, appetite changes and aches and pains. Not everyone has all of them, and they persist for weeks or months.
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What is depression, and is it a real illness?
Yes. The NHS says depression is a real illness with real symptoms, not a sign of weakness or something you can snap out of. When you are depressed you feel persistently sad for weeks or months, rather than just a few days.
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How do I know if I have depression or just low mood?
The NHS says a low mood may improve after a short period, whereas depression lasts for weeks or months and interferes with work, social and family life. See a GP if you have symptoms most of the day, every day, for more than 2 weeks.
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What is the best treatment for depression?
It depends on severity. The NHS says mild depression may be managed with watchful waiting, guided self-help, exercise or talking therapies, while moderate to severe depression is usually treated with antidepressants, often combined with talking therapy such as CBT.
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Can I refer myself for talking therapy?
Yes. The NHS says you can refer yourself directly to an NHS talking therapies service without seeing a GP, or a GP can refer you. Waiting times can be several weeks or months.
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How long do antidepressants take to work?
The NHS says symptoms should start to improve within 4 weeks of starting antidepressants. If they are working, you will usually continue them at the same dose for at least 4 to 6 months after your symptoms have eased.
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Are antidepressants addictive?
The NHS says antidepressants are not addictive in the way illegal drugs and cigarettes are, but you may get withdrawal symptoms if you stop suddenly or miss a dose. You will be advised to reduce your dose gradually.
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What causes depression?
There is no single cause. The NHS lists stressful life events, family history, personality, pregnancy and childbirth, menopause, loneliness, alcohol and drugs, and long-term illness. Different causes often combine to trigger it.
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Can you get depression during pregnancy?
Yes. The NHS calls it antenatal depression and says to talk to a midwife or GP if you often feel low and hopeless and no longer enjoy things. Treatment includes self-help, talking therapies and, for some, antidepressants that are safer in pregnancy.
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How long does depression last?
The NHS says symptoms persist for weeks or months. With treatment, it says most people can make a full recovery, and if you have had depression before you may need to continue antidepressants long term.
Where this comes from
Sources and checking.
This guide is for information, not medical advice.
Your GP or consultant knows your history and can tell you which parts apply to you. If your symptoms are severe, rapidly worsening, or come with red-flag features, seek urgent medical care. Figures and availability change, so treat them as a guide and confirm with the provider.
Published 2026-10-11, next review 2027-10-11.
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NHS: Overview - Depression in adults, https://www.nhs.uk/mental-health/conditions/clinical-depression/overview/ , retrieved October 2026
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NHS: Symptoms - Depression in adults, https://www.nhs.uk/mental-health/conditions/clinical-depression/symptoms/ , retrieved October 2026
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NHS: Causes - Depression in adults, https://www.nhs.uk/mental-health/conditions/clinical-depression/causes/ , retrieved October 2026
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NHS: Diagnosis - Depression in adults, https://www.nhs.uk/mental-health/conditions/clinical-depression/diagnosis/ , retrieved October 2026
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NHS: Treatment - Depression in adults, https://www.nhs.uk/mental-health/conditions/clinical-depression/treatment/ , retrieved October 2026
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NHS: Depression in pregnancy, https://www.nhs.uk/pregnancy/keeping-well/depression/ , retrieved October 2026
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NHS: Where to get urgent help for mental health, https://www.nhs.uk/nhs-services/mental-health-services/where-to-get-urgent-help-for-mental-health/ , retrieved October 2026
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