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Health condition

High cholesterol

Cholesterol is a major, quietly acting driver of heart attack and stroke - and one of the most fixable. Understanding your numbers is the first step to deciding whether and how to treat.

Why trust this guide

  • 01

    Editorial team

    Written by our editorial team from the UK sources listed on each page.

  • 02

    Sourced from guidance

    Checked against current NHS and UK specialist society guidance at the time of review.

  • 03

    Current for 2026

    Reviewed on 2026-09-27 with the next review scheduled for 2027-09-27.

Key facts

The essentials at a glance.

The symptoms to recognise, when to seek help, which specialist to see, and what treatment usually involves.

  • Usually silent: high cholesterol causes no symptoms - very high inherited levels can produce tendon lumps or eyelid deposits

  • Seek early assessment if total cholesterol exceeds 7.5, LDL exceeds 4.9, or a close relative had a heart attack before 60 - familial hypercholesterolaemia may run in the family

  • Specialist: a consultant cardiologist usually leads assessment and treatment

  • Options span diet and lifestyle, statins, ezetimibe, bempedoic acid and injectable PCSK9 inhibitors or inclisiran for those needing more

Understanding the condition

What it is and what happens next.

What causes it, how it is diagnosed, and the treatment routes available in the UK.

What it is and how it feels

What matters most is LDL cholesterol - the particle that penetrates artery walls and builds plaque - interpreted alongside your overall cardiovascular risk rather than in isolation. The same number can warrant reassurance in one person and treatment in another, which is why risk calculators and sometimes a coronary calcium score inform the decision.

Diagnosis and treatment routes

Lifestyle change - less saturated fat, more fibre, weight control and exercise - typically lowers LDL by 10-15%, while statins achieve 30-50% with strong outcome evidence. For those who cannot tolerate statins or need deeper reduction, ezetimibe, bempedoic acid and PCSK9-targeting injections provide effective alternatives. In many parts of the UK, routine NHS referrals for this kind of problem currently take 20-45+ weeks, whereas an initial appointment with a private consultant is typically available within around two weeks.

Seeing a specialist

Who to see, and how quickly you can be seen.

The specialist for this condition is usually a consultant cardiologist. Your GP can refer you on the NHS, or you can arrange a private consultation directly.

A quiet reminder

This guide is for information, not medical advice.

Your GP knows your history and can tell you which parts apply to you. If in doubt, see them - and seek urgent care for any of the emergency symptoms described above.

Frequently asked

Common questions about High cholesterol.

Quick, plain-English answers to what people ask us most.

  • What is high cholesterol?

    High cholesterol means the level of cholesterol, a fatty substance, in your blood is higher than recommended, particularly LDL ("bad") cholesterol, which can build up in artery walls over time and increase the risk of heart attack and stroke. Like high blood pressure, it typically causes no symptoms itself and is identified through a blood test. Cholesterol levels are influenced by both genetics and lifestyle factors.

  • What causes high cholesterol?

    Causes include diet high in saturated fat, lack of physical activity, being overweight, smoking, and genetic factors, with some people having an inherited tendency towards high cholesterol (familial hypercholesterolaemia) regardless of lifestyle. Certain medical conditions, such as an underactive thyroid or diabetes, can also raise cholesterol levels. Often lifestyle and genetic factors combine to determine an individual’s cholesterol level.

  • What are the symptoms of high cholesterol?

    High cholesterol typically causes no symptoms at all, which is why it is detected through a blood test rather than by how you feel. Very high levels, particularly with familial hypercholesterolaemia, can occasionally cause visible signs such as fatty deposits around the eyes or in tendons, though this is uncommon. This lack of symptoms in most cases is exactly why regular cholesterol checks, particularly for those with risk factors, matter.

  • Is high cholesterol dangerous?

    Yes, sustained high cholesterol, particularly LDL cholesterol, contributes to the build-up of fatty deposits in artery walls over years, significantly increasing long-term risk of heart attack and stroke. This risk accumulates silently over time, which is why it is taken seriously and treated even without symptoms. Effective management, through lifestyle changes and, where needed, medication, substantially reduces this long-term cardiovascular risk.

  • How is high cholesterol treated?

    Treatment typically starts with lifestyle changes, including a diet lower in saturated fat, regular exercise, weight management, and stopping smoking, with statin or other cholesterol-lowering medication added if lifestyle changes alone are not sufficient or if overall cardiovascular risk is high. The specific target cholesterol level and treatment approach depend on your individual overall cardiovascular risk, not cholesterol level alone. Regular monitoring helps track response to treatment and guide any needed adjustments.

  • Can high cholesterol be reversed?

    For many people, particularly those with lifestyle-related high cholesterol, meaningful diet and exercise changes can significantly reduce cholesterol levels, sometimes into a healthy range without needing medication. For people with a genetic predisposition, such as familial hypercholesterolaemia, lifestyle changes alone are often not sufficient, and medication is generally needed for effective long-term control. Even with medication, continuing healthy lifestyle habits remains valuable for overall cardiovascular health.

  • High cholesterol vs high triglycerides — what is the difference?

    Cholesterol and triglycerides are both types of fat measured in a standard lipid blood test, but they are different substances with somewhat different health implications: LDL cholesterol is particularly linked to artery-clogging plaque build-up, while high triglycerides are more specifically linked to lifestyle factors like diet, alcohol, and blood sugar control, and very high levels also carry a risk of pancreatitis. Both are relevant to overall cardiovascular risk and are usually assessed together as part of a full lipid profile. Your doctor will interpret your specific pattern of results together to guide the most appropriate management.

  • When should I get my cholesterol checked?

    Most adults should have cholesterol checked at least once by age 40, and more regularly if risk factors such as family history, obesity, or diabetes are present. A private health assessment including a full cholesterol (lipid) profile can typically be arranged within about a week. If you have a strong family history of early heart disease or very high cholesterol, ask your doctor about testing for familial hypercholesterolaemia specifically, as this needs a somewhat different management approach.