Men’s health and cancer
Penile cancer: symptoms, causes, tests and treatment
Penile cancer is very rare and mostly affects men over 50. The main symptoms are a growth, lump or sore that does not heal within 4 weeks, a rash, bleeding, a smelly discharge, difficulty pulling back the foreskin or a change in skin colour. Many causes are less serious, but see a GP promptly. Treatment depends on stage and ranges from creams to surgery.
Last checked: 2026-10-11
Key facts
At a glance.
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Very rare
The NHS says penile cancer is very rare and mostly affects men aged over 50. Cancer Research UK describes it as a rare cancer in the UK.
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A sore that does not heal
The NHS lists a growth, lump or sore that does not heal within 4 weeks as one of the most common symptoms, along with a rash, bleeding and a smelly discharge.
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HPV is a major factor
The NHS says roughly half of all penile cancers are caused by certain types of human papillomavirus (HPV). Most people with HPV will not get penile cancer.
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Biopsy confirms it
A biopsy, taking a small piece of tissue under local anaesthetic, is the main test to diagnose penile cancer, according to the NHS.
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Early cancer may need only creams or laser
The NHS says treatment for early cancer often involves non-surgical treatments such as a chemotherapy cream or laser therapy, while later cancer may need surgery, chemotherapy and radiotherapy.
What are the symptoms of penile cancer?
The NHS lists the most common symptoms below. It adds that other symptoms may include a lump in your groin, feeling tired, tummy pain and losing weight without trying. Some of these symptoms are very common and can be caused by other conditions, so having them does not definitely mean you have penile cancer.
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A growth, lump or sore that does not heal within 4 weeks.
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A rash.
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Bleeding from your penis or under your foreskin.
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A smelly discharge.
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Difficulty pulling back your foreskin (phimosis).
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A change in the colour of the skin of your penis or foreskin.
When to see a GP
The NHS advises seeing a GP if you have any changes to how your penis looks, discharge or bleeding from your penis, any of the other symptoms listed, or symptoms that are not going away. It encourages people to try not to be embarrassed, as the doctor or nurse will be used to talking about these symptoms. Finding cancer early may make it easier to treat.
At the appointment the GP may check your penis and ask you to have a blood test. They will usually ask about your general health, your symptoms, when they started and whether anything you have used has made them better or worse. If the GP thinks the symptoms could be cancer you may get an urgent referral for more tests or to see a specialist in hospital. The NHS stresses that this does not definitely mean you have cancer.
How is penile cancer treated?
The NHS says penile cancer may be more treatable if it is found early. Treatment depends on the size and type of the cancer, where it is, whether it has spread, and your age and general health.
| Treatment | What it involves | When it may be used |
|---|---|---|
| Creams | Fluorouracil (5FU), a chemotherapy cream, or imiquimod, an immunotherapy cream | Early cancer affecting the foreskin or the end of the penis |
| Laser treatment or cryotherapy | A strong beam of light, or freezing, to kill cancer cells | Small or very early stage cancer |
| Surgery | Removing the cancer and a small area around it, the top skin layer or the head of the penis, sometimes part or all of the penis, and some lymph nodes | Depends on stage; removal of part or all of the penis is only offered if no other treatment is possible |
| Chemotherapy | Medicines that kill cancer cells | With radiotherapy, before or after surgery, or if the cancer has spread |
| Radiotherapy | High-energy rays of radiation | Instead of surgery, after surgery, or to help with symptoms |
What causes penile cancer?
Roughly half of all penile cancers are caused by certain types of HPV, according to the NHS. HPV is passed on by skin-to-skin contact of the genital area, vaginal, anal or oral sex, and sharing sex toys. Most people affected by HPV will not get penile cancer.
The NHS says you might also be more likely to get penile cancer if you smoke, have problems pulling back your foreskin to keep your penis clean (phimosis), have or had treatment for psoriasis with psoralens and an ultraviolet (UVA) light source (PUVA treatment), or have a weakened immune system because of a condition such as HIV.
You cannot always prevent penile cancer, but the NHS suggests ways to lower the chance: getting the HPV vaccination if you can, using condoms, stopping smoking, and having a circumcision if you have phimosis and this is recommended as treatment.
What is penile cancer?
Cancer Research UK explains that penile cancer happens when abnormal cells in the penis start to divide and grow in an uncontrolled way. It can develop anywhere on the penis but is most common under the foreskin in men who have not been circumcised, or on the head of the penis (the glans). The NHS says most penile cancers affect the skin covering the penis (the foreskin) or the head.
It is uncommon: the NHS calls it very rare and Cancer Research UK says cancer of the penis is very rare. It can affect anyone with a penis, although it is most common in men over 50. Because so many other, much more common, conditions affect the foreskin and glans, many people with symptoms will not have cancer, but the NHS is clear that symptoms should be checked.
How is penile cancer diagnosed?
If a GP refers you to a specialist, you may need more tests. The NHS says a biopsy is the main test: a specialist takes a small piece of tissue from the affected area under local anaesthetic, and you should be able to go home on the same day. You should get the results within a few weeks, and you can call the hospital or GP if you are worried.
If cancer is found, further tests find out its size and how far it has spread, which is called the stage. The NHS lists scans such as MRI, CT or PET, and a test to see whether the lymph glands in the groin have been affected, called a lymph node biopsy. You may not have all of these tests, or any of them. You will be supported by a specialist team that includes a clinical nurse specialist who is your main point of contact.
Living with the effects
The NHS recognises that surgery may affect how the penis looks, such as its size or shape, and that this may affect how you feel about your body. It says the specialist team can answer questions about how you will pee or have sex and can explain what surgery means for you. Reconstructive surgery may be possible if the penis needs to be removed, using skin and muscle from other parts of the body.
If the cancer is advanced and cannot be cured, the NHS says treatment aims to slow growth and spread, help with symptoms and help you live longer, and you will be referred to a symptom control or palliative care team. Being told you have cancer can feel overwhelming, and the NHS points people to Macmillan Cancer Support for a free helpline.
NHS and private pathways
The NHS says that if a GP thinks your symptoms could be cancer you may get an urgent referral for more tests or to see a specialist in hospital, which does not definitely mean you have cancer. You will be supported by a team of specialists that includes a clinical nurse specialist, who is your main point of contact during and after treatment.
Some people choose to see a private urologist for a second opinion. The NHS and Cancer Research UK both signpost support: Macmillan Cancer Support has a free helpline, and Cancer Research UK has a nurse helpline.
Frequently asked
Questions people ask.
Quick, plain-English answers to the questions we hear most.
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What are the symptoms of penile cancer?
The NHS lists a growth, lump or sore that does not heal within 4 weeks, a rash, bleeding from the penis or under the foreskin, a smelly discharge, difficulty pulling back the foreskin and a change in skin colour. Other symptoms can include a lump in the groin, tiredness, tummy pain and weight loss.
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How common is penile cancer?
The NHS says it is very rare and mostly affects men over 50. Cancer Research UK also describes it as a rare cancer in the UK.
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What are the first signs?
A growth, lump or sore that does not heal within 4 weeks, a rash, bleeding, a smelly discharge, difficulty pulling back the foreskin or a change in skin colour, according to the NHS.
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Do these symptoms always mean cancer?
No. The NHS says some of these symptoms are very common and can be caused by other conditions, but it is important to have them checked by a GP.
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Does HPV cause penile cancer?
The NHS says roughly half of all penile cancers are caused by certain types of HPV, but most people with HPV will not get penile cancer.
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What is phimosis and why does it matter?
Phimosis is difficulty pulling back the foreskin. The NHS lists it as a risk factor because it makes it harder to keep the penis clean, and says circumcision may be recommended to treat it.
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How is penile cancer diagnosed?
A biopsy under local anaesthetic is the main test. Scans and a lymph node test may follow to work out the stage, according to the NHS.
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Will I lose my penis?
Not necessarily. The NHS says removing part or all of the penis is only offered if no other treatment is possible, and early cancer is often treated with creams, laser therapy or limited surgery.
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Is reconstruction possible?
The NHS says reconstructive surgery may be possible if the penis needs to be removed, using skin and muscle from other parts of the body.
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How can I lower my risk of penile cancer?
The NHS says you cannot always prevent it, but you can lower the chance by getting the HPV vaccination if you can, using condoms, stopping smoking and, if you have phimosis and it is recommended as treatment, having a circumcision. See a GP about any changes to your penis.
Where this comes from
Sources and checking.
This guide is for information, not medical advice.
Your GP or consultant knows your history and can tell you which parts apply to you. If your symptoms are severe, rapidly worsening, or come with red-flag features, seek urgent medical care. Figures and availability change, so treat them as a guide and confirm with the provider.
Published 2026-10-11, next review 2027-10-11.
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NHS: Symptoms of penile cancer, https://www.nhs.uk/conditions/penile-cancer/symptoms/ , retrieved October 2026
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NHS: Causes of penile cancer, https://www.nhs.uk/conditions/penile-cancer/causes/ , retrieved October 2026
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NHS: Tests and next steps for penile cancer, https://www.nhs.uk/conditions/penile-cancer/tests-and-next-steps/ , retrieved October 2026
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NHS: Treatment for penile cancer, https://www.nhs.uk/conditions/penile-cancer/treatment/ , retrieved October 2026
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Cancer Research UK: Penile cancer, https://www.cancerresearchuk.org/about-cancer/penile-cancer , retrieved October 2026
Related guides
Keep reading.
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Genital warts
A common HPV-related skin condition of the genital area.
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Lichen sclerosus
A skin condition that can affect the foreskin and glans.
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Prostate cancer
Another cancer affecting the male reproductive system.
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Testicular cancer
A cancer that is most common in younger men.
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Balanitis
Inflammation of the head of the penis, a common non-cancer cause of symptoms.
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Phimosis (tight foreskin)
Difficulty pulling back the foreskin.
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HPV vaccination
Vaccination against the virus linked to many penile cancers.
Read guide