Sirolimus + Ketoconazole
Major: Sirolimus toxicity; ketoconazole potent CYP3A4 inhibitor. Reduce sirolimus dose significantly; monitor levels.
Interaction Details
- Severity classification
- Mechanism of interaction
- Clinical management
- Alternative options
Clinical Significance
Major: Sirolimus toxicity; ketoconazole potent CYP3A4 inhibitor. Reduce sirolimus dose significantly; monitor levels.
Always consult with your pharmacist or healthcare provider before starting any new medications to check for potential interactions.