Medicine guide
Bisoprolol: uses, side effects and cautions
Bisoprolol is a beta blocker taken as a once-daily tablet, usually in the morning, for high blood pressure and angina, and alongside other medicines for heart failure. Tiredness and cold hands are common at first. The NHS says not to stop it without talking to your doctor.
Last checked: 2026-10-03
Key facts
At a glance.
-
Medicine type
A beta blocker.
-
Uses
High blood pressure, angina, and heart failure alongside other medicines.
-
Timing
Same time each day, usually in the morning; swallow whole and do not chew.
-
Dose changes
A doctor may start low and increase after around a week or more.
-
Pregnancy
Can be taken, but you and your baby may be offered extra checks.
-
Stopping
Do not stop without talking to your doctor, as your condition may get worse.
What bisoprolol treats
Bisoprolol treats high blood pressure and heart-related chest pain (angina) and can help manage heart failure when combined with other medicines. It belongs to the beta blocker group and is only available with a prescription. The NHS page does not name a brand.
Who needs to tell the prescriber first
Most adults can take bisoprolol. Tell your doctor if you have previously had an allergic reaction to bisoprolol or another beta blocker, have breathing problems such as asthma, low blood pressure, diabetes, kidney disease or poor blood flow in the legs (peripheral arterial disease). The NHS lists these among the situations where bisoprolol may be unsuitable or where extra care is needed.
How to take it
Swallow the tablets whole with a glass of water and do not chew them. Try to take them at the same time each day, usually in the morning, and eat as normal. A doctor may start with a low dose and increase it after around a week or more; the NHS page gives no fixed figures.
If you forget a dose, take it when you remember unless the next is nearly due, in which case skip it. Do not take two. Taking too much can sometimes be dangerous, so call NHS 111 if you have exceeded your dose.
Do not stop taking bisoprolol without talking to your doctor, because your condition may get worse. If stopping is appropriate, the dose is reduced under medical supervision.
Side effects
Headaches, tiredness and weakness, cold, numb or tingly hands and feet, dizziness from low blood pressure, and nausea or digestive upsets are the common ones. The NHS notes they usually occur when you first start or when the dose goes up, and often improve with time. Keep taking the medicine unless told otherwise, and ask a pharmacist or doctor if they bother you.
Serious but rare: allergic reactions with throat swelling or breathing difficulty, liver problems with jaundice, new breathing problems and worsening heart symptoms. Call NHS 111 if you think you may be experiencing a serious effect.
Alcohol, driving and interactions
Alcohol may increase the risk of low blood pressure. Bisoprolol does not usually affect driving, but if you feel dizzy or have vision problems after taking it, wait until these have gone.
Named medicines to mention: flecainide, clonidine, ibuprofen and amitriptyline, as well as glaucoma eye medicines and medicines to clear a blocked nose. The NHS says that is not the full list.
Pregnancy and breastfeeding
The NHS says bisoprolol can be taken during pregnancy but you and your baby may be offered extra checks; when it is needed, the benefits usually outweigh the risks to the baby. Taking it while breastfeeding may cause side effects in the baby, so doctors weigh benefits and may suggest another beta blocker. Tell your doctor if you are pregnant or nursing.
Alternatives and reporting
Other beta blockers include atenolol, metoprolol, carvedilol and nebivolol. Report suspected side effects through the Yellow Card scheme.
Frequently asked
Questions people ask.
Quick, plain-English answers to the questions we hear most.
-
What is bisoprolol used for?
High blood pressure and angina, and with other medicines it can help manage heart failure.
-
When should I take it?
At the same time each day, usually in the morning, swallowed whole with water.
-
Why are my hands and feet cold?
Cold, numb or tingly hands and feet are a common effect that often improves over time.
-
Can I stop it suddenly?
No. The NHS says not to stop without talking to your doctor because your condition may get worse.
-
Can I drink alcohol on bisoprolol?
It may increase the risk of low blood pressure, so be cautious.
-
Can I take it with asthma?
Breathing problems such as asthma are a reason to tell your prescriber first, as bisoprolol may not be suitable.
-
Is it safe in pregnancy?
It can be taken during pregnancy, with extra checks for you and your baby.
-
What if I miss a dose?
Take it when you remember unless the next is nearly due, then skip it. Never double up.
-
Which medicines interact?
The NHS names flecainide, clonidine, ibuprofen, amitriptyline, glaucoma eye medicines and nasal decongestants.
Where this comes from
Sources and checking.
This guide is for information, not medical advice.
Your GP or consultant knows your history and can tell you which parts apply to you. If your symptoms are severe, rapidly worsening, or come with red-flag features, seek urgent medical care. Figures and availability change, so treat them as a guide and confirm with the provider.
Published 2026-10-03, next review 2027-10-03.
-
NHS - Bisoprolol - about bisoprolol, https://www.nhs.uk/medicines/bisoprolol/about-bisoprolol/ , retrieved October 2026
-
NHS - Bisoprolol - how and when to take it, https://www.nhs.uk/medicines/bisoprolol/how-and-when-to-take-bisoprolol/ , retrieved October 2026
-
NHS - Bisoprolol - who can and cannot take it, https://www.nhs.uk/medicines/bisoprolol/who-can-and-cannot-take-bisoprolol/ , retrieved October 2026
-
MHRA Yellow Card scheme - the UK system for reporting suspected side effects, https://yellowcard.mhra.gov.uk/ , retrieved October 2026
Related guides