Medicine guide
Clotrimazole (Canesten): thrush, athlete's foot and ringworm
Clotrimazole, best known as Canesten, is an antifungal used on the skin and in the vagina for thrush, athlete's foot, ringworm, nappy rash, ear infections and skin fold rashes. It is sold over the counter or by prescription depending on the product. Vaginal products can weaken condoms and diaphragms, and some people should not self-treat thrush.
Last checked: 2026-10-03
Key facts
At a glance.
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Uses
Thrush (vaginal, penile and skin), athlete's foot, ringworm, nappy rash, ear infections and intertrigo.
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Forms
Skin cream (1% or 2%), vaginal cream (10%), pessaries (100 mg, 200 mg, 500 mg), solution (1%) and spray (1%).
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Skin treatment
A thin layer 2 to 3 times a day for 2 to 4 weeks; spray for up to 4 weeks.
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Pessaries
The strength decides the course: 500 mg for 1 night, 200 mg for 3 nights, 100 mg for 6 nights or 2 pessaries for 3 nights.
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Condoms
Vaginal products can damage condoms and diaphragms, and protection is affected for at least 5 days after treatment ends.
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Supply
Over the counter or on prescription, depending on type. Do not swallow it.
What clotrimazole is and where it is used
Clotrimazole is an antifungal, with Canesten as the best-known brand. The NHS lists vaginal thrush, penile and skin thrush, athlete's foot, ringworm, nappy rash, ear infections and intertrigo, the rash that forms in skin folds.
Its range of formats is wide: a skin cream in 1% or 2% strengths, a 10% vaginal cream, pessaries in three strengths, a 1% solution with a dropper and a 1% spray. Which one you need depends on where the fungus is.
On the skin and in the ear
Apply a thin layer of cream to the affected area and rub it in gently, 2 to 3 times a day for 2 to 4 weeks. The solution is applied with the plastic dropper in the same pattern. The spray is held about 15 cm away and used 2 to 3 times a day for up to 4 weeks. Keep spray away from naked flames.
Do not swallow clotrimazole. If you miss an application, put it on as soon as you remember.
Pessaries and vaginal cream
The pessary strength sets the schedule. The NHS gives 100 mg as 1 pessary every night for 6 nights or 2 for 3 nights, 200 mg as 1 every night for 3 nights, and 500 mg as a single pessary for 1 night. The 10% vaginal cream is a single dose inserted at bedtime.
Do not use these products during a period, and avoid vaginal sex during treatment. Condoms and diaphragms may be damaged and are less reliable for at least 5 days after you finish.
When not to self-treat thrush
The NHS says over-the-counter thrush treatment is not suitable if you are under 15 or over 60, have had thrush more than twice in 6 months, have or have had a sexually transmitted infection, have unusual discharge, sores, ulcers or abnormal bleeding, or if a partner has symptoms that are not the same as yours.
In those situations a pharmacist or doctor should assess you first. Tell them about earlier allergic reactions too.
The list exists because discharge and soreness can come from causes other than thrush, including infections that need a different test or treatment. Using an antifungal on the wrong problem can delay the right one, so when the picture is unclear the sensible default is to have it examined.
Side effects
On the skin, expect occasional redness, itching, irritation, burning or stinging. Vaginal products may cause pain, swelling, discharge, bleeding or lower abdominal pain. A serious allergic reaction is possible but rare; call 999 if you suspect it.
An overdose is unlikely to cause problems, but seek advice if symptoms appear.
Pregnancy, breastfeeding and interactions
Clotrimazole is generally safe in pregnancy, but check with a pharmacist or doctor first. If you are using cream or solution on the breasts, wash it off with warm water before feeding.
The NHS names tacrolimus and Solfradex ear drops as products to check. You can eat and drink normally. Suspected side effects can be reported through the Yellow Card scheme.
Frequently asked
Questions people ask.
Quick, plain-English answers to the questions we hear most.
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Can clotrimazole damage condoms?
Vaginal products can damage condoms and diaphragms, and protection is affected for at least 5 days after treatment ends.
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Who should see a doctor instead of self-treating thrush?
Under 15 or over 60, more than two episodes in 6 months, any current or past STI, unusual discharge, sores or abnormal bleeding, or a partner with different symptoms.
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How do the pessary strengths differ?
Higher strength means fewer nights: 500 mg for 1 night, 200 mg for 3 nights, 100 mg for 6 nights.
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Can I use it during my period?
No. The NHS says not to use vaginal products during menstruation.
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How long should I use the cream on athlete's foot?
Typically 2 to 3 times a day for 2 to 4 weeks. Spray can run up to 4 weeks.
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Is it safe in pregnancy?
Generally, yes, but check with a pharmacist or doctor first.
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What if I swallow some?
An overdose is unlikely to cause problems. Seek medical advice if symptoms occur.
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Do I need a prescription?
Some forms are sold over the counter and some need a prescription, depending on the product.
Where this comes from
Sources and checking.
This guide is for information, not medical advice.
Your GP or consultant knows your history and can tell you which parts apply to you. If your symptoms are severe, rapidly worsening, or come with red-flag features, seek urgent medical care. Figures and availability change, so treat them as a guide and confirm with the provider.
Published 2026-10-03, next review 2027-10-03.
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NHS medicines: clotrimazole (uses, forms, how to use it, side effects, pregnancy, interactions on one page), https://www.nhs.uk/medicines/clotrimazole/ , retrieved October 2026
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Yellow Card scheme (MHRA) - the UK system anyone can use to report suspected side effects, https://yellowcard.mhra.gov.uk , retrieved October 2026