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Allergy testing

Immunotherapy options UK

The desensitisation treatments available in the UK - tablets, drops and injections that change allergies rather than mask them.

Key facts

At a glance

  • What exists: sublingual tablets for grass pollen, tree pollen and house dust mite; injection courses for pollens, mites and insect venom.

  • Who benefits: people with allergic rhinitis uncontrolled by sprays and antihistamines, and anyone with systemic sting reactions.

  • Commitment: treatment runs for three years (five for venom), with benefits that persist after stopping.

  • Safety: first doses are given under supervision; sublingual tablets are then taken daily at home.

  • Follow-up: an allergist reviews response annually - immunotherapy is the only treatment that modifies the underlying allergy.

The full picture

What this test involves, and how to get it

Allergen immunotherapy retrains the immune system by delivering gradually meaningful doses of the very thing you react to, and it is the only allergy treatment that changes the disease rather than suppressing symptoms. In the UK the practical menu is: sublingual (under-the-tongue) daily tablets for grass pollen, tree pollen and house dust mite, taken at home after a supervised first dose; subcutaneous injection courses for pollens and mites, given in clinic with a build-up phase then monthly maintenance; and venom immunotherapy for bee and wasp allergy, the most clearly life-protective form. Courses run three years - five for venom - and benefits persist for years after completion. Candidates are people whose rhinitis remains disruptive despite properly used nasal steroids and antihistamines, and anyone with systemic sting reactions.

Access is the honest caveat: NHS immunotherapy is effective and available but concentrated in specialist allergy centres whose capacity lags demand, so waits can be long and some regions offer little. Private allergy clinics can assess within days, confirm the responsible allergen, and start sublingual treatment almost immediately or run injection programmes in-house; costs are spread over the course and confirmed upfront. Wherever it is delivered, immunotherapy is a three-year partnership - the people who do best are those who take the daily tablet as reliably in year three as in week one, with annual reviews to confirm the trajectory.

A quiet reminder

This guide is for information, not medical advice.

Your own clinician knows your history and can tell you which parts apply to you. Next review of this page: 2027-09-27.

Frequently asked

Common questions about Immunotherapy options UK.

Quick, plain-English answers to what people ask us most.

  • What is immunotherapy?

    Immunotherapy is a group of treatments that work by helping the immune system recognise and attack disease, most commonly certain cancers. Rather than directly killing abnormal cells like chemotherapy, it stimulates or redirects the body's own immune defences, and different drug classes (such as checkpoint inhibitors) work in different ways.

  • Why would a doctor recommend immunotherapy?

    Immunotherapy is usually considered for specific cancer types and stages where evidence shows it can improve outcomes, sometimes alongside surgery, chemotherapy or radiotherapy. The decision depends on the tumour type, its biological markers, and how it has responded to other treatments, so it is made by a specialist oncologist based on your individual case.

  • Do I need to prepare for immunotherapy?

    Preparation usually involves blood tests, imaging and a review of your current medications, since some drugs and pre-existing autoimmune conditions can affect suitability. Your oncology team will give you specific instructions, and it is worth being honest about any other conditions or supplements you take.

  • What happens during treatment?

    Most immunotherapy is given as an intravenous infusion in a clinic or day unit, typically over a few weeks between sessions, and you are usually monitored during and shortly after each session. Some regimens are combined with other cancer treatments, and your team will explain the specific schedule for your drug.

  • Does immunotherapy have side effects or risks?

    Because it activates the immune system, immunotherapy can cause the immune system to attack healthy tissue as well as cancer cells, leading to side effects that can affect the skin, gut, lungs, liver or hormone glands. These range from mild to serious, so any new symptoms should be reported to your care team promptly rather than waited out.

  • How long does it take to know if immunotherapy is working?

    Response is usually assessed with scans and blood markers at set intervals, often every couple of months, since the immune system can take time to act and some scans can look temporarily worse before improving. Your oncologist will interpret these results in the context of your specific cancer.

  • What happens if immunotherapy doesn't work or causes problems?

    If scans and markers show the disease is progressing, or side effects become difficult to manage, your oncologist will discuss alternative treatments, dose adjustments, or supportive care options. Treatment plans are regularly reviewed and adapted rather than fixed, so this is a normal part of ongoing cancer care.

  • How reliable is immunotherapy?

    Immunotherapy has transformed outcomes for a number of cancers, but response varies considerably between individuals and tumour types, and it does not work for everyone. Biomarker testing can help predict likely benefit, though it is not a guarantee, which is why ongoing monitoring is so important.

  • How do I get a specialist opinion on immunotherapy privately?

    You can book a consultation with a private consultant oncologist, often without needing a GP referral, who can review your diagnosis and discuss whether immunotherapy is a suitable option. Private appointments are typically available within days, giving you a dedicated specialist opinion alongside any NHS care you are receiving.