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Andrology · UK

Peyronie’s injections - curvature treated, discreetly and honestly.

Collagenase and verapamil injections placed directly into the plaque by an andrology-trained consultant urologist - with the curvature measured properly, the outcomes stated plainly, and surgery on the table only when it should be.

See indicative pricing
A radiographer guides a patient onto the bed of an advanced 3 Tesla MRI scanner in a London imaging suite

Indicative pricing

What private Peyronie’s injection treatment costs in the UK.

Indicative ranges across UK andrology clinics.

In short

£1,500–£3,500, each visit 15–20 minutes.

Treatment Indicative range
Verapamil injection course (6–12 injections) £1,500–£3,500
Collagenase (CCH) injection therapy, per cycle £2,500–£4,500
Collagenase full course (up to 4 cycles) £8,000–£15,000
Penile Doppler ultrasound and curvature assessment £350–£650
Vacuum or traction therapy programme £300–£700
Andrology consultation only £250–£450
Surgical correction (plication or grafting), if needed later £6,000–£12,000

Prices vary by clinic, by the drug - imported collagenase is always the top of the range - and by the number of cycles your plaque needs. On the NHS, Peyronie’s care is usually limited to assessment and surgery for severe stable curvature; injection therapy is rarely funded.

The problem

The right phase, the right drug, and expectations set before money is spent.

Peyronie’s care is where private medicine can quietly over-sell - injections into calcified plaques, courses priced before the ultrasound, outcomes implied rather than measured. We fix all three before you commit.

  • Map the plaque first

    A Doppler ultrasound before any course - a calcified plaque responds poorly to injections, and you deserve to know that before paying for a cycle.

  • Match the drug to reality

    Collagenase has the best evidence but limited UK availability; verapamil is accessible and modestly effective. We tell you what a clinic can genuinely provide.

  • Measure, do not impress

    Curvature in degrees at baseline and at the end - so success is a number you can see, not an adjective in a follow-up letter.

When it helps

When injection treatment is the right step.

The situations we see most, plus the one emergency that must never wait for an outpatient slot.

  • A new bend that is still changing

    Curvature in the active phase - still evolving, often with pain - is where injection therapy has its best window.

  • A palpable plaque

    The firm lump or band of scar tissue in the shaft that causes the bend - the target every injection is placed into.

  • Curvature interfering with sex

    A bend of 30 degrees or more that makes intercourse difficult or impossible - the threshold where active treatment earns its place.

  • Pain with erections

    Active-phase inflammation often hurts. Pain usually settles with time; injections and simple medication can help it along.

  • Wanting to avoid surgery

    Injections offer meaningful straightening without an operation, without shortening, and without an anaesthetic - for the right plaque.

  • Shortening, indentation or hinge

    Peyronie’s can cause waisting and hinge-like instability as well as bend - mapped on ultrasound before any treatment choice.

  • Distress and avoidance

    The condition’s psychological weight is real and under-discussed.

  • Red flag: sudden pain and bruising during sex

    A crack, immediate pain, bruising and swelling during intercourse suggests a penile fracture - that is an emergency department visit the same day, not an outpatient booking.

Treatment options

The whole ladder - not just the injections.

What each option involves - the injectable drugs, the mechanical therapies that support them, and the surgical options that wait for the stable phase.

  • Collagenase (CCH) injections

    An enzyme that dissolves the collagen of the plaque, given as paired injections in cycles with modelling in between. The best-evidenced injectable - withdrawn from routine European supply in 2020, so UK availability is via specialist import at selected clinics.

  • Verapamil injections

    A calcium-channel blocker injected into the plaque, typically every two weeks for six to twelve sessions. The most widely available UK injectable - modest but real improvements in curvature and pain.

  • Interferon alpha-2b

    An alternative injectable with trial evidence for small curvature improvements - offered in some specialist centres.

  • Penile modelling

    Gentle, structured bending of the penis against the softened plaque after injections - a core part of the collagenase protocol.

  • Traction and vacuum therapy

    Daily mechanical stretch at home, alone for mild disease or between injection cycles - helps preserve length and straighten gradually.

  • Oral and topical treatment

    Pain relief and some evidence for combination approaches; oral vitamin E and similar remedies alone have little effect on established curvature - we say so.

  • Watchful waiting

    Mild bends that do not interfere with sex need no treatment at all. Pain settles in most men within 12–18 months.

  • Surgery, for the stable phase

    Plication, plaque incision and grafting, or an implant where erectile function is poor - the definitive options once the curvature has been stable for 6–12 months.

Safety and recovery

What to expect - honestly.

Injection therapy is safe in experienced hands. The things worth planning are the phase, the drug, and expectations that match the evidence rather than the brochure.

  • An outpatient treatment, no anaesthetic beyond local

    Each session takes 15–20 minutes in clinic under local anaesthetic. You drive home; normal life continues the same day.

  • Bruising and swelling are expected

    Most men bruise after every injection, sometimes dramatically. It settles over days and is not a sign the treatment has gone wrong.

  • Realistic gains, stated up front

    Trials of collagenase show average curvature improvements around 15–20 degrees; verapamil somewhat less. Injections improve a bend - they rarely erase one.

  • Corporal rupture is the serious rare risk

    With collagenase, rupture of the erectile body occurs in well under 1 percent - the reason for the strict no-sex interval after each injection, and for treatment only in experienced hands.

  • Pain at the injection site

    Common for a day or two and controlled with simple analgesia. Persistent severe pain deserves a call, not endurance.

  • The phase matters

    Injections work best in active disease; a mature, calcified plaque responds poorly. Ultrasound tells us which you have before money is spent.

  • Erectile function

    Injection therapy does not treat erectile dysfunction, and Peyronie’s and ED often travel together - the assessment covers both, and the plan treats both.

  • The psychological side is part of the medicine

    Anxiety, avoidance and relationship strain are near-universal. Naming them - and offering psychosexual support - is part of proper care, not an optional extra.

  • Red flags after an injection

    A sudden crack or snap during erection or sex, rapidly expanding swelling, or inability to pass urine needs the emergency department the same day.

Reading your treatment record

Your treatment record in four parts. Read the last one first.

Whichever drug you are on, the letter the urologist sends after each cycle keeps to the same shape.

A UK consultant urologist reviewing a patient’s treatment records

A quiet reminder

Urology language is precise and can read coldly - ask your care team to explain anything that is unclear.

Ask your care team to explain anything that is unclear.

  1. 01 Header

    Diagnosis, phase and baseline curvature

    The documented curvature in degrees, the plaque’s size and position on ultrasound, and whether the disease is active or stable.

  2. 02 Technique

    Drug, dose and schedule

    Which agent was injected - collagenase, verapamil or interferon - the dose per session, and the planned number of cycles.

  3. 03 Findings

    Response so far

    Curvature re-measurements across the course, pain scores, and how the plaque has changed on examination and ultrasound.

  4. 04 Impression

    Next steps and the surgical question

    Read this first: whether to continue, switch or stop injections, the home traction plan, and whether surgical correction is now the better road.

Recognised by major UK insurers

BupaAXA HealthVitalityAvivaWPACignaHealixBupaAXA HealthVitalityAvivaWPACignaHealixBupaAXA HealthVitalityAvivaWPACignaHealix

Cover for Peyronie’s injection therapy varies widely - assessment is usually covered, the drug course often is not.

Frequently asked

Everything we get asked about Peyronie’s injections.

Quick answers on the drugs, availability, outcomes, cost and the surgical question.

  • What is Peyronie’s disease and what causes it?

    Peyronie’s disease is scar tissue - a plaque - forming in the elastic covering of the penis, causing curvature, shortening, indentation or pain with erections. It affects several men in every hundred, usually in middle age, and is thought to follow minor repeated injury in men with a tendency to exaggerated scarring. It is not cancer and not a sexually transmitted infection.

  • How do injections for Peyronie’s disease work?

    The drug is injected directly into the plaque. Collagenase is an enzyme that dissolves the plaque’s collagen; verapamil and interferon alter the scar-forming process. Combined with modelling or traction between sessions, a course softens the plaque and reduces the bend - typically by 15–20 degrees on average for collagenase, somewhat less for verapamil.

  • Is collagenase (Xiapex) still available in the UK?

    The manufacturer withdrew collagenase from routine European and UK supply in 2020 for commercial reasons, so it is no longer a standard NHS option. A small number of UK private clinics offer it through specialist import arrangements, at a premium.

  • Do the injections hurt, and what is recovery like?

    The plaque is numbed with local anaesthetic first, so the injections themselves are uncomfortable rather than painful. Bruising and swelling for a few days is normal and expected. You return to work the same day; sexual activity pauses for around two weeks after each injection - strictly so with collagenase, to protect against the rare risk of corporal rupture.

  • How much does private Peyronie’s injection treatment cost in the UK?

    A verapamil course of six to twelve injections typically runs £1,500–£3,500. Collagenase, where available, costs £2,500–£4,500 per cycle and £8,000–£15,000 for a full course of up to four cycles. Assessment with penile Doppler ultrasound adds £350–£650. On the NHS, treatment is usually limited to assessment, pain management and surgery for stable severe curvature - injection therapy is rarely funded.

  • Will I still need surgery afterwards?

    Some men will. Injections aim to improve curvature enough to restore comfortable sex; when the residual bend still prevents that after a completed course - or when the plaque was heavily calcified from the start - surgical correction by plication or grafting in the stable phase is the reliable fix. A good andrologist tells you at the outset which outcome your plaque makes likely, and we make sure that conversation happens before you spend anything.

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