Bioregenerative aesthetics · London
Polynucleotide injections, by a doctor who does them every week.
Bioregenerative skin quality treatment with CE-marked Plinest, Newest, Ameela, Vitaran or Nucleofill - by a GMC-registered aesthetic doctor, in a CQC-registered London clinic, with full batch traceability and no grey-market vials.
Why patients choose us
- 01
A regulated, brand-named product every time
Plinest, Newest, Ameela, Vitaran or Nucleofill - CE-marked, cold-chain stored, batch-traceable. No unlabelled vials, no grey-market imports.
- 02
An aesthetic doctor, not a trainee
A GMC-registered doctor or nurse prescriber with a high polynucleotide caseload, working in a CQC-registered clinic.
- 03
Independent, and free
We are paid by no clinic, so the recommendation is impartial and costs you nothing.
Indicative pricing
What polynucleotide injections cost in London.
Indicative ranges across our vetted London clinics. Tell us the area and we quote firm figures across two or three options.
In short
A proper face course of three sessions: £850–£1,400, visible skin change from week 8.
| Treatment | Indicative range | Typical duration | Result timeline |
|---|---|---|---|
| Consultation and skin assessment | £75–£150 | 30 min | Same visit |
| Full face - single session (2 mL, Plinest/Newest) | £280–£450 | 30–45 min | Same visit |
| Under-eye specific (Nucleofill Soft, Ameela Eyes) | £480–£850 | 30 min | Same visit |
| Face course of three sessions (recommended protocol) | £850–£1,400 | 3 sessions | 8–12 weeks |
| Neck and décolletage add-on | £200–£350 | 20 min | Same visit |
| Scalp for hair-loss adjunct (course of three) | £900–£1,500 | 3 sessions | 3 months |
Prices vary by clinic, by brand (Plinest, Newest, Ameela, Vitaran, Nucleofill) and by injector seniority. Under-eye work is priced separately because of the technique and the specific product used.
The journey
From first enquiry to visible change - what happens, in order.
A three-session course, spaced three to four weeks apart, with a review at eight to twelve weeks.
- 01
Before
You send us a few photos and your goals
A short, confidential form. Areas of concern (skin quality, under-eyes, fine lines, acne scars, hair thinning), your age, prior treatments and any skin conditions.
- 02
Before
We come back with a plan
Within one working day: whether polynucleotides fit, or whether a skinbooster, filler, exosome or energy device is a better call. Indicative price for a course of three.
- 03
Before
We book your consultation and first session
Usually within one week. A 24-hour cooling-off period between consent and injection where the doctor is new to you.
- 04
On the day
Numbing and mapping
20 minutes of topical anaesthetic. The doctor marks a grid of small injection points across the treatment area and photographs the baseline.
- 05
On the day
The injections
15 to 30 minutes. A very thin 30 or 32-gauge needle - or a blunt cannula for the under-eye - deposits small aliquots of gel into the deep dermis in a papular pattern.
- 06
On the day
Home the same hour
Small raised bumps for 12 to 24 hours, sometimes a little pinpoint bruising. No downtime, gentle skincare only for 24 hours, no exercise for a day.
- 07
After
Sessions two and three, then review
Repeat at three to four-week intervals for a total of three sessions. Skin quality builds gradually over 8 to 12 weeks. Top-up every 6 to 9 months if you want to hold the result.
When it helps
When polynucleotides are the right choice - and when they are not.
Best in the early ageing window, roughly 30 to 55, and for skin quality rather than deep volume loss.
-
Overall skin quality and glow
Dullness, laxity, roughness or a general loss of bounce in the early ageing decade - the classic indication.
-
Under-eye tear trough and crepiness
Thin, crepey lower-lid skin where filler would look puffy or lumpy - polynucleotides thicken and brighten without volumising.
-
Fine lines around eyes and mouth
Early etched lines from sun and expression, before they warrant toxin or resurfacing.
-
Rolling and boxcar acne scars
Bioregenerative remodelling of atrophic scars, usually stacked with subcision or microneedling.
-
Sensitive, reactive or rosacea-prone skin
Non-inflammatory, non-irritant and often better tolerated than lasers or peels.
-
Hair thinning - adjunct only
Scalp polynucleotides alongside minoxidil, finasteride or PRP for early androgenetic thinning. Not a standalone cure.
-
Post-procedure skin recovery
After laser, microneedling or Morpheus8 to speed healing and improve the final result.
-
When they are not the answer
Deep volume loss, jowling, heavy folds or dynamic wrinkles - these need filler, toxin or a lift, not bioregeneration.
Brands and comparisons
The polynucleotide range, and what it is not.
A quick side-by-side of the brands used in London and how polynucleotides sit alongside Profhilo, Rejuran, HA filler and PRP.
-
Plinest and Newest (Mastelli)
The original Italian polynucleotide range from purified trout sperm DNA. Plinest for face, Newest for finer areas. The most published brand.
-
Ameela and Ameela Eyes
A UK-popular polynucleotide with a dedicated periorbital formulation for the tear trough and lower lid.
-
Vitaran and Vitaran Body
Higher-concentration polynucleotide for face and body indications, including neck and décolletage laxity.
-
Nucleofill Soft, Medium, Strong
Polynucleotide plus HPT gel matrix. Soft for under-eyes, Medium and Strong for face laxity. Slightly firmer, longer-acting.
-
Not the same as Profhilo
Profhilo is thermally cross-linked hyaluronic acid. It hydrates and stimulates via HA. Polynucleotides work by bioregeneration - fibroblast activation, collagen and elastin.
-
Not the same as Rejuran
Rejuran is a Korean salmon-DNA polydeoxyribonucleotide (PDRN). Same family, slightly different molecular profile and injection technique - covered on its own page.
-
Not the same as HA filler
Filler adds volume where it is injected. Polynucleotides do not volumise - they improve the skin envelope itself. The two are often used together.
-
Not the same as PRP or exosomes
PRP uses your own platelets; exosomes use cell-derived vesicles. Polynucleotides use purified fish DNA fragments. Different mechanisms, sometimes combined.
Our vetted London network
A small panel of aesthetic clinics, we picked them.
CQC-registered clinics with GMC or NMC prescribers, cold-chain storage and batch traceability. Introductions are made privately, once we understand your goals.
-
GMC-registered doctors and NMC nurse prescribers, not beauty therapists
-
CQC-registered clinics with cold-chain storage and full batch traceability
-
Only CE-marked, MHRA-notified branded polynucleotides - no unlabelled or imported vials
-
A written treatment plan, before and after photography, and a named clinician for follow-up
Safety and expectations
What to expect, honestly.
Minimal downtime, gradual change and a firm line against unregulated product.
-
Small bumps for 12 to 24 hours
Visible pinpoint papules where the product was deposited. They flatten overnight or by the following morning. Makeup after 12 hours.
-
Bruising, mostly under the eyes
Occasional pinpoint bruises, particularly around the tear trough. Arnica helps. Avoid alcohol, ibuprofen and fish oil for 48 hours before.
-
Mild tenderness and redness
Some warmth and mild soreness for a few hours. Cold packs are fine. Paracetamol if needed.
-
Very rare allergic reaction
Polynucleotides are derived from salmon or trout sperm DNA. A true fish allergy is a contraindication - flag it at consultation.
-
Not in pregnancy or breastfeeding
As with most injectables, deferred until after pregnancy and breastfeeding. Also avoided during active skin infection.
-
Results are gradual, not immediate
You will not walk out looking transformed. Skin quality shifts over 8 to 12 weeks as fibroblasts lay down new collagen and elastin.
-
Best in the 30 to 55 window
Bioregeneration works with living, responsive fibroblasts. In your 60s and beyond the response is smaller and a combined plan usually makes more sense.
-
Beware the grey market
Unbranded or unusually cheap "polynucleotide" vials bought online may be unregulated, non-sterile or misidentified. Only accept CE-marked, batch-labelled product.
-
Red flags after treatment
Spreading redness, hot swelling, blistering, blanching or vision change under the eye - call the clinic the same day or go to A&E.
Reading your treatment record
Your polynucleotide notes in four parts. Insist on all four.
A reputable clinic records the product, batch and volume in your notes. If they will not, walk away.
- 01 Header
Product, batch and volume
Which polynucleotide brand was used (Plinest, Newest, Ameela, Vitaran or Nucleofill), the lot number and how many millilitres were placed.
- 02 Technique
Areas, depth and pattern
Which zones were treated, needle or cannula, depth of injection and the papular grid or linear-threading pattern.
- 03 Findings
Baseline photographs and skin notes
Standardised before-photos, skin type, any active concerns (rosacea, melasma, acne) and the treatment goal in your own words.
- 04 Impression
Session plan and review date
Read this first: session two in three to four weeks, expected onset at 8 to 12 weeks, and when your review photographs and top-up will be.
London clinics known for polynucleotide work
Named for context only. We introduce you privately, matched to your area, brand preference and budget.
Frequently asked
Everything we get asked about polynucleotides.
Quick answers on brands, cost, results timeline and safety.
-
What are polynucleotide injections?
Polynucleotides are short, purified DNA fragments extracted from salmon or trout sperm. Injected into the deep dermis, they act as a bioregenerative signal - stimulating fibroblasts to proliferate and to produce new collagen and elastin. The result is a gradual improvement in skin quality, thickness and elasticity rather than added volume. Common UK brands include Plinest, Newest, Ameela, Vitaran and Nucleofill.
-
How are they different from Profhilo or filler?
Profhilo is a thermally cross-linked hyaluronic acid that hydrates and bio-remodels through HA signalling. Polynucleotides work via fibroblast activation and collagen synthesis. Hyaluronic acid filler adds physical volume where it is injected. Polynucleotides do neither of those things - they improve the skin envelope itself. Many patients end up combining polynucleotides with either or both, in a staggered plan.
-
How much do polynucleotide injections cost in London?
A single 2 mL face session is typically £280 to £450. An under-eye-specific session with Nucleofill Soft or Ameela Eyes is £480 to £850. A recommended course of three face sessions runs £850 to £1,400 depending on brand, clinic and injector. A scalp course for hair-loss support is £900 to £1,500.
-
How many sessions do I need and when will I see a result?
The standard protocol is three sessions three to four weeks apart. Some patients see a subtle glow after the first session, but the meaningful change in skin quality builds gradually over 8 to 12 weeks as new collagen and elastin lay down. Most people top up every six to nine months to hold the result.
-
Are polynucleotides safe if I have a fish allergy or am pregnant?
A true, confirmed allergy to salmon or trout is a contraindication - flag it clearly at consultation. Polynucleotides are also avoided in pregnancy and breastfeeding, during active skin infection or inflammation, and in patients on active immunosuppression. Your doctor will screen for these before injecting.
-
How do I avoid grey-market or fake product?
Only be treated in a CQC-registered clinic by a GMC or NMC-registered prescriber. Ask to see the vial and its batch label before injection - the product should be CE-marked, cold-chain stored and traceable to a UK-recognised distributor. Any offer of "polynucleotides" at an unusually low price, from a non-medical setting, or from an unlabelled vial should be refused.
Match me with a clinic
Ready for a proper, brand-named polynucleotide plan?
Tell us your area of concern, your budget and your postcode. We come back within one working day with two or three vetted London options, firm prices and next available appointments.
Related treatments
Looking for something else?
-
Skinboosters (Vital, Volite, Profhilo)
HA-based hydration and bio-remodelling injectables.
Learn more -
Rejuran salmon DNA
The Korean PDRN cousin of polynucleotides.
Learn more -
Lip fillers
HA volume for the lip body and border.
Learn more -
Tear trough filler
HA volumising under the eye - when polynucleotides are not enough.
Learn more -
Exosome therapy
Cell-derived vesicle therapy for skin and hair regeneration.
Learn more -
Morpheus8 RF microneedling
Energy-based skin tightening and remodelling.
Learn more